CASP1 and infection: Interestingly, Belnacasan, an inhibitor of inflammatory class caspase 1 and 4 (S3D Fig), failed to reduce either infection or CPT-induced PS exposure (Fig 2A–2D, S3A and S3B Fig), demonstrating a similar apoptotic pathway induced by HIV and CPT and suggesting multiple classes of caspases contribute to the infection and CPT induced PS exposure.