NFE2L2 and obesity due to melanocortin 4 receptor deficiency: Studies show that 5H4PB has antifungal and anti-obesity effects [6, 7], and activates the expression of a series of antioxidant response genes that protect cells from oxidative stress via activation of the nuclear factor erythroid 2-related factor 2 (NRF2)–antioxidant response element (ARE) pathway [8].