Of the upregulated DEGs, GO pathway analysis revealed enrichment of genes linked to glutamatergic synaptic transmission and excitability, and PsychENCODE analysis identified a neuronal module of genes linked to glutamatergic excitability that are downregulated in autism spectrum disorders (Gandal et al., 2018), suggesting the possibility that CSDS-induced mPFC dendritic spine density loss and excitatory synaptic transmission are produced, in part, by one or more of these synapse-linked genes that are downregulated following stress-induced mPFC NPAS4 expression. The gene discussed is NPAS4; the disease is autism spectrum disorder.