In contrast to the upregulated genes, Npas4 shRNA-downregulated genes showed strong enrichment for ribosomal function and a PsychENCODE module (M15) of excitatory neuron genes associated with ribosome function that is upregulated in ASD and BD, and more than half of these downregulated Npas4 shRNA genes are associated with NPAS4 protein (Figure 5F). This evidence concerns the gene NPAS4 and Behcet disease.