Interestingly, CSDS increased anxiety-like behavior, as measured in the elevated plus maze, in both SC shRNAPFC and Npas4 shRNAPFC mice (Figure 2H, two-way ANOVA, main effect of CSDS, F value = 8.087 and Df = 59, p=0.0061, n = 14–18 per group), indicating that mPFC NPAS4 function is required for some, but not all, of the behavioral sequelae of CSDS. Here, NPAS4 is linked to Anxiety.