Overall, our findings reveal a novel role for mPFC NPAS4 in CSDS-induced reductions in mPFC pyramidal neuron excitatory synaptic transmission and dendritic spine loss, including the emergence of anhedonia-like behaviors, though mPFC NPAS4 did not impact CSDS-induced social avoidance or anxiety-like behavior (Figure 6). The gene discussed is NPAS4; the disease is Anxiety.