NPAS4 and Anxiety: While one report indicated that CSDS-induced reduction of dendritic spine density is associated with social avoidance phenotypes (Qu et al., 2018), we observed that mPFC NPAS4 reduction selectively blocked CSDS-induced spine loss and anhedonia-like behavior, but social avoidance and anxiety-like behavior were not impacted, suggesting that deep-layer mPFC pyramidal cell spine loss, per se, is not strictly required for CSDS-induced social- and anxiety-related phenotypes.