Misfolding and aggregation of TTR is associatedwith numerous gain-of-toxicfunction amyloid diseases called TTR amyloidoses with deposited ATTR.Today, there are many treatment options for ATTR diseases includingliver transplantation, siRNA, and antisense oligonucleotides (ASOs)for modifying TTR expression as well as small molecule kinetic stabilizersto avoid tetramer dissociation and TTR misfolding and amyloid formation.22 There is interest in generating new and improvedtreatment options, but early diagnosis is even more urgent, whichis the key for effective treatment. The gene discussed is TTR; the disease is amyloidosis.