Butt et al. postulated that constitutive LASP1 phosphorylation by active BCR::ABL1 prevents CXCR4 stabilisation by LASP1, limiting CXCL12-CXCR4 signalling, and favouring cellular trafficking of CML cells from the BM into the periphery [27]. The gene discussed is CXCL12; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.