Regarding tumor DNA, there were two mutated genes in one patient (CDH1 and MUC6), five mutated genes in two patients (including BNC2, FAT4, APC, TP53, CREBBP), and ten mutated genes in two patients (CDH1, PIK3CA, SMAD4, MUC6, FAT4, APC, RNF43, KMT2D, CTNNB1, ARID1A). This evidence concerns the gene RNF43 and neoplasm.