Based on the immunohistochemical analysis of IL-1β in tumor tissue on day 10, the number of positive cells (brownish-yellow staining) ranged from 76 to 100% in the hMSCshSTC1 group, while it ranged from 5 to 20% in the hMSCshCtrl group, indicating that hMSC could suppress TME and STC1 knockdown significantly diminished this impact (Figure 4B). Here, IL1B is linked to neoplasm.