The expression of all genes belonging to the SARC‐HRD signature was significantly upregulated and the expression of MDM2 significantly decreased in patient‐derived HRDhigh sarcoma cells compared with HRDlow (Figs 5D and EV4D), thus validating the SARC‐HRD gene signature in an independent sarcoma cohort. Here, MDM2 is linked to sarcoma.