Our analysis showed an upregulation of 10 genes in HRDhigh sarcoma: BRCA1, BRCA2, BLM, EME1, FANCB, FANCD2, FANCI, RAD51, RAD54L and XRCC2 (Figs 4A and C, and EV3), which we named SARC‐HRD signature, as well as enrichment of genes in the HRR pathway (Fig 4B). Here, EME1 is linked to sarcoma.