Meanwhile, we found that a patient with KIT gene exon 17 D816H secondary mutation obtained PFS for 9 months, which was consistent with the results of in vitro study.7 Anlotinib also showed a good therapeutic effect in the cases of PDGFRA D842V mutation and SDHB- deficient GIST. This evidence concerns the gene SDHB and gastrointestinal stromal tumor.