Previously, NR3C1 methylation changes at select CpG sites have been documented following exposure to severe psychological and emotional stress, trauma, and neglect (Palma‐Gudiel et al., 2015), as well as exposure to maternal psychological stress and depression, though many of the results are discordant and highly variable in timing of outcome, exposure, and methylation tissue type (Berretta et al., 2021). This evidence concerns the gene NR3C1 and major depressive disorder.