NR3C1 and depressive disorder: NR3C1 hypermethylation is also associated with many poor health outcomes including depression (Melas et al., 2013), borderline personality disorder (Dammann et al., 2011; Steiger et al., 2013), and cancer (Kay et al., 2011; Lind et al., 2006; Nesset et al., 2014).