Apelin/APJ mRNA expression in WAT and muscles, plasma apelin level, and activation of the NLRP3 inflammasome in WAT, IL-1 β, IL-6, tumor necrosis factor-α, and monocyte chemoattractant protein-1 levels in plasma, insulin resistance, survival rates, and endothelial nitric oxide synthase phosphorylation in soleus muscles. This evidence concerns the gene NOS3 and Insulin resistance.