The examples vary from well-established CNV loci (e.g., LPA with heart disease loci) through partially understood CNV loci (e.g., the UGT1A gene in porphyrin and bilirubin metabolism) to very credible associations to paralogues with the same phenotype (the RCHE gene in pregnancy complications) or credible novel alleles in a gene with robust association to a phenotype (HERC gene with hair color). The gene discussed is UGT1A1; the disease is heart disorder.