MAPT and Cognitive impairment: Previous studies indicated that THY-Tau22 mice develop Tau pathology from the age of 3 months onwards, including hyperphosphorylated and misfolded Tau species that were associated with changes in synaptic plasticity and cognitive impairments, (Schindowski et al., 2006; van der Jeugd et al., 2011, 2013; Ahmed et al., 2015; Vautheny et al., 2021).