ADAM10 and Alzheimer disease: Indeed, α-secretase attenuating mutations within the prodomain of ADAM10, the major α-secretase that generates secreted APPsα, were identified in families with late onset AD (Suh et al., 2013; Agüero et al., 2020) and more recently, ADAM10 was also linked to sporadic AD through genome-wide association studies (Kunkle et al., 2019).