In this regard, previous studies had indicated that APPsα overexpression in neuroblastoma cells can inhibit GSK3β (Deng et al., 2015) and that incubation of primary neurons with recombinant APPsα (recAPPsα) resulted in downregulation of CDK5 expression and activity (Hartl et al., 2013) in vitro. The gene discussed is GSK3B; the disease is neuroblastoma.