RhoA signaling has been directly implicated in neurodegenerative diseases, including Alzheimer’s disease (AD), Picks disease (PiD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis (ALS; Huesa et al., 2010; Aguilar et al., 2017; Schmidt et al., 2022). Here, RHOA is linked to Alzheimer disease.