TNF and glaucoma: Interestingly, genetic deletion of CD11b, a cell-surface integrin expressed by activated myeloid cells, or Tnf-α, a powerful proinflammatory effector critical for macrophage function (Parameswaran and Patial, 2010), has been shown to ameliorate RGC loss in mouse models of glaucoma (Nakazawa et al., 2006).