Indeed, one of the most highly up-regulated molecules downstream of ApoE signaling in glaucoma was Galectin-3, a secreted carbohydrate binding lectin previously implicated in a myriad of CNS degenerations (Jiang et al., 2009; Boza-Serrano et al., 2019; Siew et al., 2019). Here, LGALS3 is linked to glaucoma.