This transcriptional profile, termed the MGnD, highlighted several key genes shared with the DAM signature (e.g., ApoE, Trem2, Spp1, Clec7a) with increased attention to proinflammatory mediators such as Ccl2. Krasemann et al. (2017) further demonstrated that DAM microglia are spatially localized around Aβ plaques in AD and that ApoE expression is positively correlated with severity of disease in mouse models of MS and ALS. This evidence concerns the gene APOE and Alzheimer disease.