In contrast, it is possible that the deleterious role for the DAM signature in glaucoma represents pathogenic interactions between microglia and recruited monocytes, whereby ApoE expression in long-lived resident myeloid cells is necessary to initiate the inflammatory response (Margeta et al., 2022) but recruited monocyte-derived macrophages play a key pathogenic role (Howell et al., 2012; Williams et al., 2019; Chen et al., 2020). Here, APOE is linked to glaucoma.