As shown in Figure 3(d), the eight of these pathways are viral protein crosstalk with cytokines and cytokine receptors, cushing syndrome, p53 signaling pathway, cell cycle, ferroptosis, Wnt signaling pathway, estrogen signaling pathway, and IL-17 signaling pathway. This evidence concerns the gene TP53 and Cushing syndrome due to macronodular adrenal hyperplasia.