Furthermore, adoptive transfer of these IL-10+ B cells (regulatory B cells) in Plasmodium berghei ANKA-infected mice resulted in a significant reduction in NK and CD8+ T-cell accumulation in the brain and also prevented cerebral hemorrhage, whereas, using the same susceptible model of experimental cerebral malarial C57BL/6, a different study reported that there is need of three cycles of infections followed by treatment for the development of mice resistant to cerebral malarial. Here, IL10 is linked to infection.