Secretory pathways such as endoplasmic reticulum processing, exocytosis, and protein transport were specifically upregulated, which implied that gmsweet15 mutant may have organized more abundant extracellular peptides such as PR1 as a weapon oppose primary infection of S. sclerotiorum, which was consistent with gmsweet15_24 h exhibiting higher PR1 expression than WT_24 h (Supplementary Table S3). Here, TMEM37 is linked to infection.