FAT1 and hydrops fetalis: The detailed FA profile (Tables S1) exhibited a significant reduction of total ω-6 PUFA (P < .05) associated with the increase of total ω-3 PUFA (P < .05) in Fat-1-HF mice compared with WT-HF mice resulting in a reduced ω-6/ω-3 ratio (P < .001), which was also observed in the Fat-1-LF group (P < .001) (Figure 4J).