Interestingly, adipose tissue-specific N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD) knockout (KO) mice display an obese phenotype and dyslipidemia, which have been linked to a shift in gut microbiota populations and a decrease in particular of the Allobaculum genus.84N-acylphosphatidylethanolamine phospholipase D is a key enzyme involved in the biosynthesis of NAEs, and, accordingly, these KO mice exhibit lower adipose tissue levels of PEA and OEA. This evidence concerns the gene NAPEPLD and metabolic syndrome.