GLUT1, as a target gene of HIF-1, is involved in the regulation of glucose metabolism together with LDHA and MCT-4, and some studies have found that even in the presence of GLUT1 inhibitors (such as WZB117), if platelet-derived growth factor is stimulated, it increases glycolysis, intracellular lactate content and other acidic metabolites in colon cancer cells and promotes tumor progression (Table 1) (165, 166). This evidence concerns the gene LDHA and colonic neoplasm.