Microenvironmental hypoxia as well as abnormal HIF-1 activity in tumor cells are one of the causes of resistance to chemotherapy and/or radiotherapy in solid tumors (107–109).This is partly because most of the patients with CRC have problems of chemoresistance, recurrence and metastasis, it is necessary to explore the key targets and drugs to reverse resistance and improve the therapeutic efficacy. This evidence concerns the gene HIF1A and neoplasm.