HK2 is most closely related to malignant tumors, and dioscin has been shown to promote ubiquitination and degradation of c-myc by enhancing the binding of the E3 ligase FBW7 to c-myc, which helps to inhibit HK2 and inhibit glycolysis in CRC cells to exert antitumor activity (172). The gene discussed is HK2; the disease is cancer.