Oridonin is an active diterpenoid isolated from Rabdosia rubescens in the 1970s (167), which can rapidly inactivate p-AMPK, down-regulate the expression of GLUT1 and MCT-1 while inhibiting glucose uptake, reduce lactate output, and induce autophagy and death in CRC cells. The gene discussed is SLC2A1; the disease is colorectal carcinoma.