CD4 and colorectal carcinoma: Lactic acid(LA) promoted the expression of CXCL10 and Cadherin-11 in CD115+ precursor cells through the PI3K-AKT pathway, and CXCL10 stimulates the recruitment of CD4+ T cells to the metastatic site and induces RANKL production, leading to CRC bone metastasis (51, 52).