IDF-11774 is a HIF-1 inhibitor that targets HSP70 and inhibits mitochondrial respiration, activates AMPK and downregulates HIF-1α expression in HCT116 cells under hypoxia, and inhibits extracellular acidification rate (ECAR) and oxygen consumption rate (OCR) in cancer cells by downregulating HIF-1α target gene expression reducing glucose uptake, lactate levels, and NAD+ and NADP+ contents (Table 1) (146, 147). Here, HIF1A is linked to cancer.