Studies performed in transgenic fat-1 mice that carry a C. Elegans gene, fat-1, encoding an n-3 fatty acid desaturase catalysing the conversion of n-6 to n-3 PUFAs (48) (these mice have low concentrations of AA and high amounts of EPA and DHA in their plasma and tissues) revealed that these animals do not develop T1DM when challenged with STZ (49). This evidence concerns the gene FAT1 and type 1 diabetes mellitus.