(8) found that compared to normal controls, six lysine residues (Lys103, Lys206, Lys276, Lys296, Lys534, and Lys640) and one arginine residue (Arg678) were modified via glycation in the serum Tf of type 2 diabetic patients, as assessed by shotgun proteomics and heavy water (2H2O)-based metabolic labeling method. Here, TF is linked to type 2 diabetes mellitus.