Recently, with the continuous improvements in technologies, such as proteomics and glycometabolomics, and the rapid development of related detection technologies, including high-performance liquid chromatography/electrospray ionization-mass spectrometry (HPLC/ESI-MS), studies have shown that non-enzymatic glycated modification of transferrin (Tf) is closely related to the occurrence and development of diabetes and its complications (8–12). Here, TF is linked to diabetes mellitus.