It is interesting to note that RIPK1 knockout in twitcher mice (a line for modeling Krabbe disease) did not slow down the disease progression, and the symptoms did not differ from normal twitcher mice, which, apparently, may be due to the feature of the line where genes downstream in the RIPK1 cascade are already defective, so its contribution is unnoticed (Cachón-González et al., 2021). Here, RIPK1 is linked to Krabbe disease.