An increase in RIPK1 was observed in the brain of a person who died of HD (Vitner et al., 2014), and increased expression of RIPK3 and MLKL was found in macrophages derived from stem cells from patients with Gaucher disease, indicating that necroptosis plays a role in triggering inflammation-related cell death in Gaucher disease (Messelodi et al., 2021). Here, RIPK1 is linked to Gaucher disease.