PCSK1 and Parkinson disease: Suppression of necroptosis by Nec-1 reduced 6-hydroxydopamine-induced death of PC12 cells (Wu et al., 2015), protected mice from dopamine cell loss in the modeling of PD using subchronic administration of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine), which causes permanent symptoms of Parkinson’s disease (20 mg/kg MRTR intraperitoneally daily within 5 days), and also increased survival of iPSCs derived from patients with PD (Iannielli et al., 2018).