While the pathognomonic neuropathological features of Alzheimer’s Disease [AD; the most prevalent cause of existing cognitive impairment in surgical patients (Xie and Tanzi, 2006)] are β-amyloid (Aβ) plaques and neurofibrillary tangles from hyperphosphorylated tau protein, neuroinflammation (evidenced by activated microglia/upregulated pro-inflammatory cytokines) is also identified in postmortem brain samples from AD patients (Kinney et al., 2018). This evidence concerns the gene MAPT and Alzheimer disease.