Examples of disease-associated misfolded proteins are tau and amyloid beta in Alzheimer’s disease (AD), alpha-synuclein in Parkinson’s disease (PD), TDP43 and SOD1 in amyotrophic lateral sclerosis and amylin in type 2 diabetes (Mukherjee et al., 2015; Soto and Pritzkow, 2018). The gene discussed is TARDBP; the disease is Alzheimer disease.