HLA-DRB1 and diabetes mellitus: HLA-DRB1*0301 and HLA-DRB1*04 genotypes were associated with T1D in this population compared to controls. The protective haplotype HLA-DRB1*15 was more common in controls (25/152, 16.4%; OR 0.20) than in T1D patients (7/188, 3.7%). SNPs within the HLA region; HLA-DQB1 locus (rs9273363) and HLA-DQB1 region (rs1063355) showed positive signals. T1D GRS was significantly higher in diabetes participants compared to controls, 0.189 ± 0.064 vs 0.154 ± 0.067.