Some HLA-DRB1 alleles showed significant association with T1D compared to controls; DRB1*04:05, OR of 14.76 (95%CI 4.99-58.83), DRB1*09:01, OR of 3.48 (95%CI 1.52-8.33) and DRB1*03:01, OR of 2.82 (95%CI 1.59-5.03). DRB1*15:03 was protective for T1D with OR 0.27 (95%CI 0.09-0.65). Here, HLA-DRB1 is linked to type 1 diabetes mellitus.