Ten (52.6%) of 19 T1D patients had DR3 positivity compared to 15/50 (30%) controls. Only 2 T1D (11%) and 2 control (4%) participants were DR4 positive. The frequency of DR2 in the T1D patients was low (4/19 vs 23/50). Here, TNFRSF25 is linked to type 1 diabetes mellitus.