Serum anti-glycoprotein antibodies were assessed in one study of 42 patients with IPAA (Table 2).21 The cohort included 13 patients with recurrent, acute pouchitis, encompassing patients with episodes of antibiotic-responsive pouchitis with repeated flares up to four times per year, 13 with chronic pouchitis, defined as patients requiring antibiotic or anti-inflammatory therapy for at least 4 weeks, or patients having more than five flares per year, 10 with a normal pouch, and five with FAP. This evidence concerns the gene ART4 and pouchitis.