Werner et al. did find a significant difference in the sera and stool concentration of glycoprotein 2 autoantibodies in patients with chronic pouchitis and recurrent acute pouchitis compared to patients with a normal pouch or in healthy relatives.60 In addition, a subset of chronic pouchitis patients with Crohn’s-like disease complications—strictures, fistulae, and pre-pouch inflammation, had significantly higher sera and stool titers of glycoprotein 2 compared to patients with chronic pouchitis without these complications. Here, GP2 is linked to inflammatory response.