ERK phosphorylation is refractory to EGFR inhibition in human BRAFV600E-mutant CRC cell lines 22,23, however, the FAK-EGFR interaction was still detected in HT29 CRC cells and the interaction was not affected by either EGFR inhibition or FAK inhibition (Supplementary Fig. 3e). The gene discussed is PTK2; the disease is colorectal carcinoma.