A recent report using next-generation sequencing to characterize EBNA1 sequence variation in an Australian cohort of MS patients also found low levels of variation in EBNA1 and suggested that although it is unlikely that there is an encephalitogenic strain of EBV, EBNA1 sequence variation does map to HLA-DRB1 binding sites, potentially effecting inflammatory and autoreactive T cell responses40. The gene discussed is HLA-DRB1; the disease is myeloid sarcoma.