Accordingly, PCSK9 LOF or pharmacological inhibition during sepsis may lead to the significant reduction in these dysfunctional lipids with consequent beneficial effects on endothelial dysfunction.26 On the contrary, further lowering of already low HDL and LDL among children, may result in drop below a critical threshold of these lipoproteins, which are essential for maintenance of vascular health and clearance of bacteria and endotoxin. Here, PCSK9 is linked to endothelial dysfunction.