IL17A and airway hyperresponsiveness: Furthermore, treatments with DNase I and Cl-amidine resulted in comparable reduction of asthma features to simvastatin-treated mice, including reduced perivascular and peribronchial leukocyte infiltration (Figures 2(f) and 2(g)); less mucus production (Figures 2(h) and 2(i)); reduced airway hyperresponsiveness (Figure 2(j)); lower BALF total cells, neutrophil counts, and eosinophil counts (Figures 2(k) and 2(l)); reduced concentrations of BALF IL-1β, INF-γ, IL-4, and IL-17A (Figures 2(m) and 2(n)); and lower lung Th2 and Th17 cell counts and higher Treg cell counts (Figures 2(o)–2(r)).