Nuclear factor erythroid 2-related factor 2 (Nrf2), which is immediately downstream of ROS, promotes the expressions of antioxidant response element- (ARE-) dependent genes to maintain cellular redox homeostasis, protect cells from apoptosis as well as oxidative stress damage, and balance oxidative mediators, thereby alleviating the development of Dex-induced osteoporosis [9–11]. The gene discussed is NFE2L2; the disease is osteoporosis.