IDH1 and central nervous system cancer: Recently, several molecular markers implicated in the regulation of cancer cell proliferation and death have been utilized for prognostic prediction and pathological diagnosis of gliomas, including the mutations in isocitrate dehydrogenase (IDH), codeletion of the short and long arms of chromosomes 1 and 19, respectively (1p/19q), and O6-methylguanine-DNA methyltransferase (MGMT) methylation [5].