MYD88 was selected to verify the reliability of our model in vitro because of the following reasons: (i) MYD88 was a risk factor upregulated significantly in gliomas relative to normal tissues and correlated with a poor prognosis, (ii) MYD88 was one of the top 5 hub genes in the PPI network, (iii) the coefficient of MYD88 was the maximum in our signature, and (iv) the involvement of MYD88 has been previously reported in LPS-induced pyroptosis [30]. Here, MYD88 is linked to central nervous system cancer.