After myocardial infarction, inflammatory cytokines show aggregation in the area near the infarct, with increased expression of pro-inflammatory factors and decreased expression of anti-inflammatory mediators, while exogenous FGF21 can effectively inhibit the inflammatory response and fibrosis in the post-infarction heart, thus exerting cardioprotection (Li et al., 2021). The gene discussed is FGF21; the disease is myocardial infarction.