In the univariate logistic regression analysis, the occurrence of heart failure in STEMI patients was used as the dependent variable, and gender, age, presence of hypertension, diabetes mellitus, atrial fibrillation, blood cholesterol, triglycerides, LDL-C, HDL-C, uric acid, creatinine, troponin I, NT-proBNP, FGF21, pulmonary pressure, mitral regurgitation, LAD, IVST, LVPWT, LVEDD, LVESD, LVEDV, LVESV, LVM, LVEF, and multiple coronary lesions as independent variables. The gene discussed is FGF21; the disease is mitral valve insufficiency.