According to the ROC curve analysis, the AUC of NT-proBNP to predict the occurrence of heart failure during hospitalization in STEMI patients was 0.929 (95% CI [0.901–0.957]) (Fig. 2), while the AUC of FGF21 was 0.816 (95% CI [0.770–0.863]). This evidence concerns the gene NPPB and heart failure.