The univariate Logistic regression analysis found that LDL-C, HDL-C, troponin I, NT-proBNP, FGF21, LAD, LVEDD, LVESD, LVESV, LVM, LVEF were associated with heart failure during hospitalization in STEMI patients (P < 0.05) (Table 3). This evidence concerns the gene NPPB and heart failure.