The humoral immune response mainly involves the Toll and the immune deficiency (IMD) pathways, which share great similarities with the mammalian MyD88-dependent Toll-like receptor (TLR) and tumor necrosis factor receptor pathways (TNFR), respectively (Anthoney, Foldi & Hidalgo, 2018; Prakash, Roychowdhury-Sinha & Goto, 2021). This evidence concerns the gene TLR4 and Immunodeficiency.