ALDH1A1, as an aldehyde dehydrogenase, can transform precursor retinaldehydes into retinoic acid receptor (RAR) (Kiefer et al., 2012) and has been found to promote PCa invasion and metastasis through the activation of RARα (Jiang et al., 2020). This evidence concerns the gene ALDH1A1 and posterior cortical atrophy.