In gliomas, there are both OXPHOS-dependent cells and glycolytic-dependent cells, the mechanism lies in the lactate dehydrogenase (LDH), the former expressed both LDH-A and -B isoforms whereas the latter only expressed LDH-B and LDH-B would be expected to be essential for the use of extracellular lactate to fuel cell activities 11. This evidence concerns the gene LDHB and central nervous system cancer.