Several results displayed the LPH-PolyMet could high efficiently silence the expression of VEGF mRNA (down to 5%) in NSCLC tumor cell H460, and then induced apoptosis in about 40% of cells, which implied that PolyMet play dual roles as both a gene carrier and an antitumor drug to achieve combinational therapeutic efficacies against cancer. This evidence concerns the gene VEGFA and non-small cell lung carcinoma.