Chosen the Bcl-2 protein overexpressed cells (MDA-MB-231) as the model, the assay data showed a dramatic reduction of Bcl-2 expression (down to 20%) with these co-delivery nanomedicines; remarkably, the level of early apoptosis was significantly increased from 6% to 18%, which implied that the siRNA could sensitized the resistant cancer cells and then enhanced the anticancer effect of BZT. The gene discussed is BCL2; the disease is cancer.