BCL2 and cancer: In addition, various co-deliver system of mixed-point distribution were developed, such as Tf-modified co-encapsulated DOX- and pEGFP-loaded SLN for targeting lung cancer 91, the first use of nanoscale metal-organic frameworks (UiO-NMOFs) for the co-delivery of cisplatin and MDR gene-silencing siRNAs (Bcl-2, P-glycoprotein and survivin) to enhance therapeutic efficacy 92 and γ-cyclodextrin and multiple oligoethylenimine arms with folic acid (γ-CD-OEI-SS-FA) co-deliver paclitaxel PTX and p53 gene for potential cancer therapy 57 (Figure 6F).