TWIST1 and posterior cortical atrophy: As shown in Fig. 1D-H, PCa-OBCM enhanced EMT function by upregulating N-cadherin and Twist expression, and suppressing E-cadherin expression; levels of vimentin, Snail, ZEB1, and ZEB2 expression were unchanged (Fig. 1D-G; Supplementary Fig. 1A&B).