Whereas some research has shown that Hsp90β elevates levels of Twist expression by increasing Twist protein stability that ultimately influence Twist translocation from the cytoplasm to the nucleus in hepatocellular carcinoma 46, other research has reported that antiapoptotic Bcl-2 switches on Twist nuclear localization signals and results in the transcriptional activation of EMT under hypoxic conditions 47. This evidence concerns the gene TWIST1 and hepatocellular carcinoma.