HIF1A and liver cancer: Mechanistically, the accumulation of intracellular copper ions induced by the downregulation of COMMD10 can inhibit the ubiquitin-mediated degradation of HIF-1α, subsequently increasing the transcription and translation of ceruloplasmin, which forms a positive feedback regulation loop of HIF-1α/CP to inhibit ferroptosis, thereby promoting the radiotherapy resistance of liver cancer cells 187.