Analysis of ATM mutation frequency in The Cancer Genome Atlas (TCGA) cohort using c-Bioportal 25,26 indicated that ATM is frequently mutated in multiple human cancers, with a higher mutation frequency of 40% in mantle cell lymphoma, and approximately 20-35% in cutaneous, uterine, lung and colorectal cancers (Fig. S1A). Here, ATM is linked to cancer.