In this study, we found that activation of the FGFR1 signaling enhances the phosphorylation of both ERK1 and ERK2, and inhibition of MEK to prevent the activation of both ERK1 and ERK2 blocked the FGFR1 signaling-induced FOXQ1 upregulation and breast cancer cell proliferation. The gene discussed is MAPK3; the disease is breast carcinoma.