1e). Furthermore, inhibition of FGFR function by FGFR inhibitors, AZD4547 39 and/or LY2874455 40, not only abolished AP20187- or bFGF-induced FOXQ1 mRNA expression but also further downregulated the basal expression level of FOXQ1 mRNA as compared to the FOXQ1 mRNA expression level in vehicle-treated DCIS-iFGFR1 (line #1) and MDA-MB-231 cells (Fig. This evidence concerns the gene FGF2 and ductal breast carcinoma in situ.