The network pharmacological analysis ofphenolic acids identified 6 monomeric compound (>50 genes, such as caffeic acid, rosmarinic acid, ferulic acid, salvianolic acid B,salvinal, salvianolic acid A), 30 genes (IL-6, AKT1, VEGFA, STAT3, TNF, TP53, APP, etc.), and 20 target gene-regulated pathways (AGE-RAGE, HIF-1, cAMP signaling pathway, etc.)associated with ischemic stroke. Here, TP53 is linked to ischemic stroke.