COP1 and Autoimmunity: The present study provides substantial evidence on the inhibitory effect of INDP on NO production, to aid in understanding the mechanisms through which protective autoimmunity promotes neuroprotection after SCI. The neural-derived peptides A91 and Cop-1 were used to immunize rats with SC injury. In vitro studies showed that INDP significantly reduced the production of NO by glial cells. While in vivo experiments demonstrated that INDP reduced the amount of NO and iNOS gene expression at the site of injury