MBP and Autoimmunity: It was observed that high-dose (2 mg/kg) administration of GA impaired locomotor recovery, which worsen lesion pathology with higher spinal neuron loss in the acute phase after spinal cord injury. Moreover, high-dose GA in the acute phase after SCI amplified autoimmunity against MBP with increasing proliferative responses. Thus suggesting that high-dosage immunotherapy with GA in the acute phase after spinal cord injury exhibited neurodestructive effects which further devastated any neuroprotective effect of T-cell