Additionally, sEng was demonstrated to induce arterial hypertension via Bone morphogenetic protein 4 (BMP4) (Gallardo-Vara et al., 2020), and high plasma sEng levels are associated with preeclampsia symptoms and placental abnormalities, suggesting the crucial role of sEng in preeclampsia development (Pérez-Roque et al., 2020). Here, BMP4 is linked to Hypertension.