ENG and preeclampsia: Indeed, it was demonstrated that human sEng affected mouse endoglin signaling and aggravated mice aortic endothelial dysfunction (Vitverova et al., 2018), mice cholesterol and BA metabolism (Dolezelova et al., 2019), mice NASH (Igreja Sa et al., 2020) and induced symptoms of preeclampsia in mice (Venkatesha et al., 2006).