This mechanism was also proved by some cases who did the marrow biopsy from our AA case series (Michot et al., 2017) (Helgadottir et al., 2017) (Meyers et al., 2018) (Younan et al., 2021), which showed activated CD8+ lymphocytes that were suggestive of immune-mediated aplastic anaemia. Here, CD8A is linked to aplastic anemia.