Besides, a meta-analysis study based on 2,946 patients from four studies also discovered that ipilimumab/nivolumab may result in higher all- and high-grade irAEs compared with nivolumab alone, including pruritus, rash, diarrhea, colitis, alanine aminotransferase elevation, and pneumonitis (Zhou et al., 2019). The gene discussed is GPT; the disease is pneumonitis.