IDH1 and astrocytoma (excluding glioblastoma): Figure 1C showed the ALOX5 protein level in LGG and normal tissues. Besides, ALOX5 was significantly related to age and subtype (all p < 0.01), but had no significant relation with gender, IDH status, race, and laterality (Table 1) (Figure 1D). Of note, ALOX5 expression was upregulated in LGG patients aged ≤40 years compared with those aged >40 years. Astrocytoma patients seems to exhibit the highest ALOX5 mRNA expression, followed by the mixed type, and oligodendroglioma patients (all p < 0.01) (Figure 1D).