The results showed that the expression of DSC3, DLL3, BMP6, SEMA4D, and GHRH are increased (p < 0.05) in melanoma, while the expression of LRRC4B, SFRP1, DCN, and CCL-8 decreased in melanoma (p < 0.05; Figure 12). The gene discussed is DLL3; the disease is melanoma.