Then, we identified 9 LR pairs (“BMP6- > HJV” 、"CCL8- > ACKR4” 、"DLL3- > NOTCH3"、"DSC3- > DSG3"、"GHRH- > GHRHR” 、"LRRC4B- > PTPRF"、"SEMA4D- > PLXNB1"、"SFRP1- > FZD6"、"UCN- > CRHR1′′) as key LR pairs in melanoma prognosis through Lasso Cox regression and Multiple Stepwise Regression. The gene discussed is SFRP1; the disease is melanoma.