For example, zebrafish that lack lphn3.1 (one of two Lphn3 orthologs) were found to be hyperactive (Lange et al., 2012, 2018)–an effect that was attenuated by the ADHD medications methylphenidate and atomoxetine (Lange et al., 2012). The gene discussed is ADGRL3; the disease is attention deficit-hyperactivity disorder.