ADGRL3 and attention deficit-hyperactivity disorder: Mapping of this region has revealed that variants in the Lphn3 (Adgrl3) gene (OMIM 616417) predispose individuals to ADHD (Acosta et al., 2008, 2011, 2016) and predict ADHD severity and response to treatment (Arcos-Burgos et al., 2010; Acosta et al., 2011; Bruxel et al., 2015).