The remaining five hub genes are also involved in several immune response pathways or various immunologic disease pathways, including viral protein interaction with cytokine and cytokine receptor (GAP43, GRIA1, NEFL, SNAP25, and SYT1), primary immunodeficiency (GAP43, GRIA1, NEFL, SNAP25, and SYT1), autoimmune thyroid disease (GRIA1, NEFL, SNAP25, and SYT1), and maturity-onset diabetes of the young (GAP43, NEFL, and SNAP25), among others. The gene discussed is GAP43; the disease is autoimmune thyroid disease.