After comprehensive analysis, we found low NEFM expression to be associated with immune responses (B-cell receptor signaling pathway, Th1 and Th2 cell differentiation, etc.)and various immunologic disease pathways (systemic lupus erythematosus, intestinal immune network for IgA production, etc.), and the neuroinflammation response (NF-kappa B signaling pathway, IL-17 signaling pathway, etc.). Here, IL17A is linked to systemic lupus erythematosus.